Table 1.
Comparison of gene expression patterns in the skin biopsy of vitiligo patients before and after treatment
| Skin biopsy expression | ||||||
|---|---|---|---|---|---|---|
| Pathway | GENE | Unaffected skin (Means ± SD) | Vitiligo skin (affected) (Means ± SD) | Repigmented after treatment (Means ± SD) | Not Repigmented after treatment (Means ± SD) | P-value |
| Pigmentation | DCT | 2.965 ± 0.554 | 0.714 ± 0.947 | 2.729 ± 0.804 | 0.590 ± 0.897 | A**; C**; D**;F** |
| MC1R | 1.148 ± 0.822 | 0.602 ± 0742 | 1.013 ± 0.788 | 0.529 ± 0.621 | A**; C**; D**; F** | |
| MC4R | 0.113 ± 0.387 | 0.000 ± 0.000 | 0.083 ± 0.316 | 0.076 ± 0.252 | E* | |
| MLANA | 2.793 ± 0.505 | 0.476 ± 0.745 | 2.488 ± 0.653 | 0.454 ± 0.699 | A**; B*; C**;D**; F** | |
| TYRP1 | 3.544 ± 0.343 | 1.214 ± 0.920 | 3.451 ± 0.463 | 1.230 ± 0.983 | A**; C**; D**; F** | |
| Apoptosis | CASP3 | 2.361 ± 0.692 | 2.521 ± 0.302 | 2.335 ± 0.545 | 2.268 ± 0.703 | D*; E* |
| TNFRSF1A | 3.158 ± 0.310 | 3.179 ± 0.246 | 3.054 ± 0.303 | 3.136 ± 0.230 | D** | |
| Cell survival | CDC5L | 3.377 ± 0.199 | 3.373 ± 0.174 | 3.291 ± 0.190 | 3.359 ± 0.250 | B*; D* |
| MITF | 3.014 ± 0.522 | 2.862 ± 0.248 | 2.980 ± 0.238 | 2.643 ± 0.605 | C**; D*; E*; F** | |
| Cellular Oxidative Stress Response |
GPD1 | 2.624 ± 0.779 | 2.668 ± 0.753 | 2.805 ± 0.552 | 2.336 ± 0.907 | E*; F** |
| TXN | 4.203 ± 0.238 | 4.310 ± 0.128 | 4.289 ± 0.136 | 4.315 ± 0.132 | A**; B*;C** | |
| Signal transduction | CSNK1G3 | 2.252 ± 0.662 | 2.408 ± 0.365 | 2.238 ± 0.703 | 1.981 ± 0.944 | E** |
The data are shown as the means ± standard deviation. (A) Unaffected vs Vitiligo skin; (B) Unaffected vs Regimented; (C) Unaffected vs Not repigmented; (D)Vitiligo vs Repigmented; (E) Vitiligo vs Not repigmented; (F) Repigmented vs Not repigmented. (*) Denotes p<0.05, and (**) denotes p<0.01.