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. 2018 Nov 20;8:527. doi: 10.3389/fonc.2018.00527

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Copyright © 2018 Mast and Kuppusamy.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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TNBC xenograft tumor does not respond to hyperoxygenation. Oxygen concentration (pO₂) in TNBC xenograft tumors was measured during room-air breathing (baseline) and the end of 20 min of hyperoxygenation (100% oxygen) administered via nose-cone breathing. The plot shows the value of hyperoxygen pO₂ as a function of baseline pO₂. The error bars indicate SEM of measurement in the respective values. The results indicate that all, but one, of the tumors studied (N = 9) do not respond to hyperoxygenation suggesting that the TNBC tumors are not only severely hypoxic, but also resistant to hyperoxic intervention.