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. 2018 Nov 20;8:527. doi: 10.3389/fonc.2018.00527

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Copyright © 2018 Mast and Kuppusamy.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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TNBC xenograft tumor growth is effectively inhibited by a combination of radiation, paclitaxel and hyperoxygenation treatments. Mice bearing TNBC xenograft tumors were treated with periodic hyperoxygenation, 1 h per day (Ox), and/or paclitaxel (Pax) in addition to radiation (IR) treatment once per week with 6 Gy. Data represent tumor volume (Mean ± SEM; N = 3–6) per treatment group for the entire period (A) and on days 0 and 21 (B) for the Control (no treatment), IR, IR+Pax, IR+Ox, and IR+Pax+Ox groups. All four treatment groups show significantly smaller volume than control group (p-values: Control vs. IR, 0.012; Control vs. IR+Pax, 0.012; Control vs. IR+Ox, 0.003; Control vs. IR+Pax+Ox,0.0004). Tumor group treated with IR+Pax+Ox shows significantly smaller tumor volume than that treated with radiation alone (p = 0.030).