Motor tests |
Raising rat by tail |
Normal response-balanced suspension |
0 |
Flexion of forelimb |
1 |
Hindlimb flexion |
2 |
Head moves 10 degrees off vertical axis within 30 s |
3 |
Place rat on floor |
Normal walk |
0 |
Inability to walk straight |
1 |
Circling toward paretic side |
2 |
Falls down to paretic, ipsilateral side |
3 |
Sensory tests |
Placing Test |
Normal response-forelimb placed on table |
0 |
No forelimb placement in response to contralateral whisker stimulation |
1 |
Proprioceptive test |
Normal response-Forepaw resistance to contralateral lateral push |
0 |
No forelimb resistance to contralateral lateral push tactile stimulation |
1 |
Balance tests |
Balances with steady posture |
0 |
Grasps side of the beam |
1 |
Hugs beam and 1 limb falls down from beam |
2 |
Hugs beam and 2 limbs fall down from beam, or spins |
3 |
Attempts to balance on beam but falls off (>40 s) |
4 |
Attempts to balance on beam but falls off (>20 s) |
5 |
Falls off; no attempt to balance or hang on to beam (<20 s) |
6 |
Reflex absence and abnormal movements |
Cotton Swab into ear canal |
Normal response-head shake/pinna reflex |
0 |
Lack of pinna reflex |
1 |
Cotton Swab touches cornea |
Normal response-eye closes/cornea reflex |
0 |
Lack of corneal reflex |
1 |
Loud hand clap |
Normal response-Jumping movement/startle reflex |
0 |
Lack of startle reflex |
1 |
Observe daily for 5 min |
Normal response-no unusual motor behavior |
0 |
Seizures, myoclonus, and/or myodystony |
1 |