Skip to main content
. 2017 Oct 12;39(6):998–1011. doi: 10.1038/aps.2017.128

Table 2. Components of the modified neurological severity score (mNSS).

Methods and observations for specific deficits Scores
Motor tests
Raising rat by tail
Normal response-balanced suspension 0
Flexion of forelimb 1
Hindlimb flexion 2
Head moves 10 degrees off vertical axis within 30 s 3
Place rat on floor
Normal walk 0
Inability to walk straight 1
Circling toward paretic side 2
Falls down to paretic, ipsilateral side 3
Sensory tests
Placing Test
Normal response-forelimb placed on table 0
No forelimb placement in response to contralateral whisker stimulation 1
Proprioceptive test
Normal response-Forepaw resistance to contralateral lateral push 0
No forelimb resistance to contralateral lateral push tactile stimulation 1
Balance tests
Balances with steady posture 0
Grasps side of the beam 1
Hugs beam and 1 limb falls down from beam 2
Hugs beam and 2 limbs fall down from beam, or spins 3
Attempts to balance on beam but falls off (>40 s) 4
Attempts to balance on beam but falls off (>20 s) 5
Falls off; no attempt to balance or hang on to beam (<20 s) 6
Reflex absence and abnormal movements
Cotton Swab into ear canal
Normal response-head shake/pinna reflex 0
Lack of pinna reflex 1
Cotton Swab touches cornea
Normal response-eye closes/cornea reflex 0
Lack of corneal reflex 1
Loud hand clap
Normal response-Jumping movement/startle reflex 0
Lack of startle reflex 1
Observe daily for 5 min
Normal response-no unusual motor behavior 0
Seizures, myoclonus, and/or myodystony 1