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miRNA-200c reserved paclitaxel resistance in A549/TAX cells induced by CTSL. (A and B) The effects of CTSL knockdown and miRNA-200c inhibition on IC50 of A549/TAX cells to paclitaxel and CTSL overexpression and added miRNA-200c on the IC50 of A549 cells were determined by MTT assay. (C) Hoechst staining was performed to determine the effects. At least three independent experiments were performed. *P<0.05, **P<0.01, and ***P<0.001 compared with control group.
