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. 2018 Oct 3;16(6):7123–7130. doi: 10.3892/ol.2018.9547

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Copyright: © Han et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 2. — Mean expressions of serum AKR1B10 and AFP levels in patients with HCC at different pathological stages classified using Barcelona Clinic Liver Cancer staging. (A) A significant increase in AKR1B10 was observed in early- and intermediate-stage HCC. ^aP<0.05 vs. patients with early stage. ^bP<0.05 vs. patients with intermediate stage. ^cP<0.05 vs. patients with advanced stage. (B) A significant increase in AFP was observed in advanced- and terminal-stage HCC. ^aP<0.05 vs. patients with early stage. ^bP<0.05 vs. patients with intermediate stage. ^cP<0.05 vs. healthy control. (C) The ratio of AKR1B10: AFP at different HCC stages. ^aP<0.05 vs. patients with early stage. ^bP<0.05 vs. patients with intermediate stage. AKR1B10, aldo-keto reductase family 1 member B10; AFP, α-fetoprotein; HCC, hepatocellular carcinoma.