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. 2018 Dec;24(12):2262–2269. doi: 10.3201/eid2412.180272

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This is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited.

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Genetic characterization of RDEx444, a strain of Escherichia coli serotype O80:H2 isolated in France in February 2016 and involved in hemolytic uremic syndrome with bacteremia, carrying both intestinal and extraintestinal virulence factors associated with (multidrug-resistance determinants (A) and genetic comparison between plasmid pS88 and mosaic plasmid pR444_A (B). A) Four circularized contigs (chromosome of 5,256,050 bp and the 3 plasmids pR444_A [176,500 bp], pR444_B [117,090 bp], and pR444_C [95,050 bp]) obtained by using PacBio (Pacific Biosciences, Meno Park, CA, USA) sequencing of RDEx444 are schematically represented. The main virulence factors are presented as colored rectangles. Intestinal virulence factors are indicated in red for the locus of enterocyte effacement genes, blue for prophage-encoded Shiga toxin genes, and green for VFs carried by pR444_C, a pO157-like plasmid. Bacteriocin genes (mch, cia, and cma) are indicated in yellow. B) Comparison of the sequences of pR444_A and pS88, the plasmid of strain S88 involved in neonatal meningitis. LEE, locus of enterocyte effacement.