(A and B) Counts of individuals with first CR E. coli detection by ward location. Detections on days 0 and 1 of admission are excluded. Faint vertical lines correspond to the boundaries of the 4 time periods, as follows: period 1 (P1), prior to implementation of a systematic CPE rectal screening policy; period 2 (P2), implementation of a CPE rectal screening policy consistent with national guidance; period 3 (P3), closure of wards 3 and 4 and replacement of plumbing infrastructure; period 4 (P4), reopening of wards 3 and 4 to patient admissions. (C) Incidence rate ratios for rates of first positive CR E. coli detection, carbapenem-resistant K. pneumoniae detection, and any CRE detection ≥2 days postadmission, relative to period 2 in the same location (MHC versus the rest of CMFT). An incidence rate ratio is not shown for period 3 in the MHC due to unit closure during this period, to facilitate plumbing replacement.