TABLE 1.
Antibacterial activity of C109 against select Gram-negative and Gram-positive bacteria
| Strain | Features | MIC (µg/ml)a | Source |
|---|---|---|---|
| Acinetobacter baumannii ATCC 19606 | Reference strain | 16 | ATCC |
| Burkholderia cenocepacia K56-2 | ET12 lineage cystic fibrosis clinical isolate | 8 | 73 |
| Burkholderia cenocepacia J2315 | ET12 lineage cystic fibrosis clinical isolate | 8 | 74 |
| Enterobacter aerogenes ENT001 | Urine meropenem-resistant isolate | 32 | A. Kumar |
| E. aerogenes ATCC 13048 | Reference strain | 8 | A. Kumar |
| Escherichia coli ATCC 25922 | Reference strain | 8 | ATCC |
| E. coli 117782 | ESBL-positive clinical isolate | 4 | G. Zhanel |
| E. coli 120955 | ESBL-positive clinical isolate | 8 | G. Zhanel |
| Klebsiella pneumoniae 119178 | ESBL-positive clinical isolate | 32 | G. Zhanel |
| Mycobacterium abscessus 13NC740779 | Ciprofloxacin-resistant clinical isolate | 4 | H. Adam |
| M. abscessus 14NF251095 | Ciprofloxacin-resistant clinical isolate | 4 | H. Adam |
| M. abscessus 14NJ168168 | Ciprofloxacin-resistant clinical isolate | 4 | H. Adam |
| M. abscessus 16NH386647 | Ciprofloxacin-resistant clinical isolate | 8 | H. Adam |
| Pseudomonas aeruginosa PAO1 | Common lab strain, from burn wound | 256 | A. Kumar |
| P. aeruginosa PA7 | Nonrespiratory clinical isolate | 128 | A. Kumar (75) |
| P. aeruginosa PA14 | High virulence burn wound isolate | >128 | Joseph Lam (76) |
| Salmonella enterica serovar Typhimurium | SGI1 genomic island; multidrug resistant | 64 | 77 |
| Serratia marcescens Db11 | Streptomycin-resistant strain | 16 | 78 |
| Staphylococcus aureus ATCC 25923 | Methicillin-sensitive reference strain | 4 | ATCC |
a
MIC values are given as the median of three biological replicates.