TABLE 3.
C109 has additive effects with common antibiotics used against B. cenocepacia
| Antibiotic | K56-2 MIC alone (μg/ml) |
K56-2 FIC index with C109a |
Interpretation | J2315 MIC alone (μg/ml) |
J2315 FIC index with C109a |
Interpretation |
|---|---|---|---|---|---|---|
| Meropenem | 32 | 0.625 | Additive | 32 | 0.508 | Additive |
| Piperacillin | 8 | 0.625 | Additive | 256 | 0.560 | Additive |
| Tobramycin | 512 | 0.625 | Additive | 512 | 2 | Additive |
| Ciprofloxacin | 2 | 1 | Additive | 8 | 2 | Additive |
| Ceftazidime | 64 | 0.625 | Additive | ND | ND | |
| Doxycycline | 4 | 0.625 | Additive | ND | ND | |
| Novobiocin | 8 | 0.75 | Additive | ND | ND | |
| Trimethoprim | 8 | 0.75 | Additive | 512 | 2 | Additive |
| Chloramphenicol | 32 | 1 | Additive | ND | ND |
a
Reported is the median FIC index from three biological replicates. ND, not determined.