TABLE 1.
Patient demographic and clinical characteristicsa
| Demographic or clinical characteristic | Value for all patients (n = 26) |
|---|---|
| Median age (yr) (range) | 50 (21–73) |
| % (no.) men | 62 (16) |
| % (no.) of patients of white race | 100 (26) |
| % (no.) of patients not Hispanic or Latino | 100 (26) |
| Median wt (kg) (range) | 63.4 (36–108) |
| Median BMI (kg/m2) (range) | 24.0 (16.6–33.2) |
| % (no.) of patients with cachexia (BMI, <18.5) | 19 (5) |
| % (no.) of patients with normal wt (BMI, 18.5–24.9) | 38 (10) |
| % (no.) of overweight patients (BMI, 25.0–29.9) | 27 (7) |
| % (no.) of obese patients (BMI, ≥30) | 15 (4) |
| % (no.) of patients with type of transplant | |
| Lung | 81 (21) |
| Liver | 8 (2) |
| Heart | 8 (2) |
| Pancreas/kidney | 4 (1) |
| % (no.) of patients with underlying disease | |
| Cystic fibrosis | 27 (7) |
| % (no.) of patients with requirement for renal replacement therapy | |
| Patients on HD | 19 (5) |
| Patients on CRRT | 23 (6) |
| Mean concn ± SD (range) for laboratory test | |
| AST (IU/liter) | 24 (0.8–173) |
| ALT (IU/liter) | 19 (10–248) |
| ALP (IU/liter) | 70 (22–491) |
| Bilirubin (mg/dl) | 0.7 (0.3–6.5) |
| Albumin (g/dl) | 2.85 (2–4.3) |
| Creatinine (µmol/liter) | 146 (53–345) |
| CrCl (ml/min/1.73 m2)b | 52 (19–115) |
a
All data were collected at the time of enrollment, prior to ISA administration. BMI, body mass index; AST, aspartate aminotransferase; ALT, alanine aminotransferase; ALP, alkaline phosphatase; CrCl, creatinine clearance; HD, hemodialysis; CRRT, continuous renal replacement therapy.
b
CrCl = {[140 – age (years)] × weight (kilograms) × 0.85 for females × 1.73}/[0.818 × serum creatinine (micromoles per milliliter) × BSA], where BSA (square meters) equals [height (meters) × weight (kilograms)/36]1/2.