TABLE 3.

Factors associated with AUC_{0–24 h} and C_trough^a

Factor	Linear regression P value
	AUC0–24 h	Ctrough
Age	0.69	0.77
Sex	0.02	0.03
Cystic fibrosis	0.44	0.60
Liver transplant	0.30	0.76
Time from transplant	0.72	0.66
BMI	0.049	0.07
BMI of <18.5 kg/m2	0.004	0.002
HD versus none	0.048	0.08

^aHD, hemodialysis; BMI, body mass index; C_trough, trough concentration at steady state; AUC_{0–24 h}, area under plasma concentration-versus-time curve from time zero to 24 h after dosing.