TABLE 1.
Parameter estimates for all parameters for the combination of meropenem plus fosfomycin against Pseudomonas aeruginosa
| Parametera | Mean | Median | SD |
|---|---|---|---|
| VMero (liter) | 17.7 | 18.2 | 0.827 |
| VFos (liter) | 27.7 | 28.0 | 1.87 |
| CLMero (liter/h) | 11.5 | 11.8 | 0.736 |
| CLFos (liter/h) | 6.84 | 7.02 | 0.524 |
| Kg-s (h−1) | 0.229 | 0.134 | 0.221 |
| Kkill-s (h−1) | 8.44 | 9.92 | 2.25 |
| E50-Mero-s (mg/liter) | 359 | 258 | 336 |
| E50-Fos-s (mg/liter) | 5,085 | 2,585 | 5,775 |
| αs | 8.67 | 9.87 | 2.34 |
| Kg-Mero-r (h−1) | 0.174 | 0.0474 | 0.267 |
| Kkill-Mero-r (h−1) | 8.82 | 8.64 | 0.803 |
| E50-Mero-r (mg/liter) | 1,834 | 279 | 2,467 |
| αmero-r | 8.35 | 9.73 | 1.96 |
| Kg-Fos-r (h−1) | 0.168 | 0.0591 | 0.207 |
| Kkill-Fos-r (h−1) | 8.35 | 8.65 | 1.53 |
| E50-Fos-r (mg/liter) | 3,608 | 3,379 | 1,101 |
| αFos-r | 8.44 | 9.1 | 1.17 |
| HMero-s | 3.05 | 2.05 | 1.55 |
| HFos-s | 2.55 | 1.97 | 0.885 |
| HMero-r | 2.19 | 1.35 | 1.30 |
| HFos-r | 1.54 | 1.24 | 0.658 |
a
V, volume of the central compartment; CL, drug clearances; Kg, growth rate constant for organisms; Kkill, kill rate constants for a subpopulation; E50, drug concentration at which the kill rate is half maximal; α, drug interaction constant; H, Hill’s constant for a subpopulation; Fos, fosfomycin; Mero, meropenem; s, susceptible; r, resistant.