TABLE 2.
Plazomicin plasma pharmacokinetic parameters by renal function groupa
| PK parameter | Normal renal function (n = 6) |
Mild renal impairment (n = 6) |
Moderate renal impairment (n = 6) |
Severe renal impairment (n = 6) |
|---|---|---|---|---|
| Cmax (mg/liter) | 37.9 ± 5.01 | 32.8 ± 4.30 | 39.2 ± 6.43 | 41.4 ± 7.83 |
| AUC0–∞ (mg · h/liter) | 136 ± 17.2 | 138 ± 23.7 | 281 ± 96.0 | 647 ± 259 |
| Vss (liters) | 36.0 ± 7.76 | 28.5 ± 2.17 | 25.8 ± 6.96 | 25.1 ± 7.89 |
| CLT (liters/h) | 4.64 ± 1.17 | 3.98 ± 0.481 | 2.25 ± 0.685 | 0.96 ± 0.379 |
a
All values are reported as mean ± SD. PK, pharmacokinetics; Cmax, maximum concentration of drug in plasma; AUC0–∞, area under the concentration-time curve from 0 h to infinity; Vss, volume of distribution at steady state; CLT, total clearance.