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. 2018 Nov 26;62(12):e01128-18. doi: 10.1128/AAC.01128-18

TABLE 3.

Pairwise comparisons of plazomicin plasma pharmacokinetic parameters by renal function groupa

PK parameter Pairwise group comparison geometric mean ratio (90% CI), P value
Mild renal impairment/normal
renal function		 Moderate renal impairment/normal
renal function		 Severe renal impairment/normal
renal function
Cmax (mg/liter) 0.87 (0.753–0.997), 0.093 1.03 (0.883–1.21), 0.719 1.08 (0.899–1.30), 0.460
AUC0–∞ (mg · h/liter) 1.01 (0.849–1.19), 0.942 1.98 (1.51–2.60), 0.0023 4.42 (3.04–6.44), 0.0003
a

PK, pharmacokinetic; CI, confidence interval; Cmax, maximum concentration of drug in plasma; AUC0–∞, area under the concentration-time curve from 0 h to infinity.