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Overexpression of PVT1 activated the MAPK/NF-κB pathway. Phosphorylation levels of p38, NF-κB, JAK2 and STAT3 in the sham group, CLP group, CLP + LV-vector group and CLP + LV-shPVT1 group. PVT1, plasmacytoma variant translocation gene 1; CLP, cecal ligation and puncture; LV, lentivirus; sh, short hairpin RNA; NF-κB, nuclear factor-κB; JAK2, Janus kinase 2; STAT3, signal transducer and activator of transcription; p-, phosphorylated. *P<0.05.
