TABLE.

Comparison of Different MRI Methods to Access Neurovascular Unit Perfusion

	DCE	DSC	SS
Contrast	GBCA ferumoxytol	GBCA ferumoxytol	Ferumoxytol
Model parameters	ktrans, vp, ve, IAUC	CBV, CBF, MTT	CBV
Spatial resolution	1 mm in plane	2 mm in plane	0.41 mm in plane
Slice thickness	5 mm	5 mm	2.2 mm
Geometric artifact	Low impact	Prone to problems at the skull base	Prone to problems at the skull base
Dynamic	Yes	Yes	No
Total acquisition time	3-5 min	2 min	8 min

DCE = dynamic contrast-enhanced, DSC = dynamic susceptibility contrast-enhanced, k^trans = transfer constant, v_p = fractional volume of the plasma space, v_e = fractional volume of the extravascular-extracellular space, IAUC = initial area under the contrast agent concentration-time curve, CBV = cerebral blood volume, CBF = cerebral blood flow, MTT = mean transit time.