Figure 1.

Chronic cadmium exposure delays skin wound healing in mice. C57B/L6 mice were given 0 or 30 mg/l CdCl₂ for different periods of time (A), or different concentrations of CdCl₂ for 8 weeks (B) through drinking water, 6-mm diameter wounds were made on the back, and the wound areas were measured at different times after injury. Data in (A) and (B) are expressed as mean ± SE, n = 5 per group. All experiments were repeated at least 3 times with similar results and representative data are shown. *P < .05, **P < .01, compared mice treated with 30 mg/l CdCl₂ for 5 or 8 weeks with corresponding untreated mice (A); compared mice treated with 10 or 30 mg/l CdCl₂ with untreated mice (B); ^##P < .01, ^###P < .001, compared 50 mg/l CdCl₂ treated mice with untreated mice, at the same time points (B). (C) Representative pictures of skin wound healing of mice exposed to different concentrations of CdCl₂ for 8 weeks. Bar = 5 mm.