Figure 6.

Effect of chronic camium exposure on proinflammatory cytokine production, MAP kinases and NF-κB activation in skin wounded tissues. Skin wounded tissues from mice intake CdCl₂ in drinking water (0, 30 mg/l) for 8 weeks were examined for the expression of proinflammatory cytokines at mRNA levels at different times after injury (A), at protein levels 3 h after injury (B), and for phosphorylation of MAP kinases and NF-κB p65 at 3 h after injury by Western blot (C). A, B, Data are expressed as mean ± SE, n = 10 per group. *P < .05, **P < .01 compared with untreated control mice at same time points after skin punch. C, Images shown are representative of 3 independent experiments, data are mean ± SD, n = 5 per group, *P < .05, **P < .01 compared with untreated mice at 3 h after skin injury.