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. 2018 Sep 19;16(6):4445–4456. doi: 10.3892/etm.2018.6763

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Copyright: © Yan et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 4. — hUC-MSCs reduce mRNA levels of inflammatory cytokines in the colon. Mice were divided into PBS, OVA, Medium/OVA and MSC/OVA treatment groups. Distal colons were collected following sacrifice on day 38. mRNA levels of (A) IL-4 and (B) TNF-α in the colon tissues were quantified using reverse transcription-quantitative polymerase chain reaction. **P<0.01; ***P<0.001. hUC-MSC, human umbilical cord-derived mesenchymal stem cell; IL, interleukin; OVA, ovalbumin; TNF, tumor necrosis factor; Medium/OVA, group challenged with OVA and administered Dulbecco's modified Eagle's medium/nutrient mixture F12; MSC/OVA, group challenged with OVA, intraperitoneal injection of hUC-MSCs and oral gavage of MSC culture supernatant.