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. 2018 Oct 19;16(6):5272–5279. doi: 10.3892/etm.2018.6883

Figure 6.

Figure 6.

miR-182-5p promotes Pal-induced lipotoxicity of INS-1 cells by directly targeting THBS-1. (A and B) MTT analysis was used to detect the cell viability of palmitate-amended INS-1 cells when miR-182-5p was overexpressed or inhibited. Data are expressed as the mean ± standard deviation. (C) Cell apoptosis rate was detected in Pal-treated cells when the expression of miR-182-5p was altered. *P<0.05 and **P<0.01 vs. Pal/miR-NC. (D and E) Restoration of THBS-1 counteracted the effect of miR-182-5p on cell viability of Pal-treated INS-1 cells. (F) Ectopic expression of THBS 1 neutralized the alteration of cell apoptosis rate induced by miR-182-5p. *P<0.05 and **P<0.01 as indicated. miR, microRNA; Pal, palmitate.