Table 1. Cytotoxic activity (mean IC50±SEM) of LASSBio-1586 analogs and the CA-4 and LASSBio-1586 standards in tumor cell lines and peripheral blood mononuclear cells (PBMCs) after 72h of treatment (IC50 values are in µmol.L-1). SEM, standard error of the mean; IC50, the concentration of a compound needed to reduce cell growth by 50% in vitro.
| Compound | HL60 (mean IC50±SEM) | OVCAR-8 (mean IC50±SEM) | HCT-8 (mean IC50±SEM) | PBMCs (mean IC50±SEM) |
|---|---|---|---|---|
| LASSBio-1837 | 0.047±1.0×10-3 | 0.099±0.010 | 0.27±0.020 | 0.24±0.045 |
| LASSBio-1839 | 0.34±0.028 | 1.26±0.24 | 1.08±0.25 | 0.51±0.020 |
| LASSBio-1840 | 0.10±0.031 | 0.39±0.031 | 0.34±0.068 | 0.43±8.1×10-4 |
| LASSBio-1917 | 0.074±0.018 | 0.55±0.37 | 0.48±0.032 | 0.71±4.0×10-3 |
| LASSBio-1918 | 0.75±0.085 | 4.26±0.20 | 4.18±0.17 | 2.14±0.61 |
| LASSBio-1919 | 0.081±0.029 | 0.31±0.19 | 0.33±0.019 | 0.33±0.086 |
| LASSBio-1920 | 3.0×10-4±4.0×10-5 | 9.0×10-3±6.0×10-3 | 5.0×10-3±3.0×10-3 | 0.10±0.011 |
| CA-4 | 2.2×10-3±3.0×10-4 | 5.0×10-4±1.0×10-4 | 5.0×10-3±1.0×10-3 | 3.2×10-3 |
| LASSBio-1586 | 0.29±1.2×10-3 | 0.29±0.040 | 0.45±0.081 | 1.34±0.065 |