Table 2. Cytotoxic selectivity index (SI), which represents the IC50 for PBMCs/cancer cell lines after 72h of treatment. PBMCs, peripheral blood mononuclear cells; SEM, standard error of the mean; IC50, the concentration of a compound needed to reduce cell growth by 50% in vitro.
Compound | SI PBMC/HL-60 | SI PBMC/OVCAR-8 | SI PBMC/HCT-8 |
---|---|---|---|
LASSBio-1920 | 333.30 | 11.11 | 20.0 |
LASSBio-1586 | 4.60 | 4.60 | 3.0 |
CA-4 | 1.45 | 6.40 | 0.60 |