TABLE 3.
P2Y12 Response Unit Assay Before and After Transfusiona
| n | % of Total | % Therapeutic T0, PRU | PRU T0, Mean (SD) | % Therapeutic T6, PRU | PRU T6, Mean (SD) | PRU Change, Mean (SD) | Apheresis Units of Platelets Transfused | PRU Change per Unit of Platelet Transfused, Mean (SD) | P, Fisher Exact Test for Therapeutic PRU | P, Wilcoxon Signed-Rank Test for PRU Change | |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Aspirin only | 66 | 62 | 38 | 252 (60) | 0 | 305 (63) | 33 (64) | 1.3 (0.8) | 26 (60) | .05 | .21 |
| Clopidogrel only | 9 | 8 | 56 | 211 (82) | 33 | 259 (79) | 48 (50) | 1.9 (1.4) | 41 (47) | .64 | .03b |
| Both agents | 32 | 30 | 78 | 183 (76) | 53 | 246 (91) | 67 (52) | 1.4 (0.6) | 50 (46) | .06b | >.001b |
| Any aspirin | 98 | 92 | 65 | 206 (78) | 40 | 260 (88) | 60 (56) | 1.3 (0.7) | 45 (49) | .03b | >.001b |
| Any clopidogrel agent | 41 | 38 | 73 | 189 (77) | 49 | 249 (88) | 62 (52) | 1.5 (0.8) | 48 (46) | .04b | >.001b |
aPRU, P2Y12 response unit response unit; T0, at admission; T6; at 6 hours.