Table S1.
Results of the univariable and multivariable Cox regression analysis before combining the subgroups with similar OS
| Demographic or clinicopathologic characteristic | Univariable analysis P | Multivariable analysis | |
|---|---|---|---|
| Hazard ratio (95% CI) | P | ||
| Sex | <0.001 | <0.001 | |
| Female | Reference | ||
| Male | 1.168 (1.128–1.210) | <0.001 | |
| Marital status | <0.001 | <0.001 | |
| Married | Reference | ||
| Unmarried | 1.093 (1.055–1.132) | <0.001 | |
| Race | <0.001 | <0.001 | |
| White | Reference | ||
| Black | 0.949 (0.901–0.999) | 0.047 | |
| Others | 0.682 (0.639–0.727) | <0.001 | |
| Age at diagnosis, years | <0.001 | <0.001 | |
| ≤61 | Reference | ||
| 62–73 | 1.152 (1.108–1.198) | <0.001 | |
| ≥74 | 1.288(1.228–1.352) | <0.001 | |
| Histology | <0.001 | <0.001 | |
| Adenocarcinoma | Reference | ||
| Squamous cell cancer | 1.260 (1.200–1.312) | <0.001 | |
| Large cell cancer | 1.157 (1.037–1.290) | 0.009 | |
| Others | 1.172 (1.118,1.229) | <0.001 | |
| Grade | <0.001 | <0.001 | |
| I | Reference | ||
| II | 1.027 (0.888–1.188) | 0.719 | |
| III | 1.248 (1.085–1.436) | 0.002 | |
| IV | 1.486 (1.206–1.829) | <0.001 | |
| Unknown | 1.167 (1.017–1.339) | 0.028 | |
| T stage | <0.001 | <0.001 | |
| T0, T1 | Reference | ||
| T2 | 1.237 (1.165–1.313) | <0.001 | |
| T3 | 1.318 (1.239–1.402) | <0.001 | |
| T4 | 1.293 (1.218–1.374) | <0.001 | |
| Tx | 1.296 (1.202–1.397) | <0.001 | |
| N stage | <0.001 | <0.001 | |
| N0 | Reference | ||
| N1 | 1.196 (1.115–1.282) | <0.001 | |
| N2 | 1.289 (1.232–1.349) | <0.001 | |
| N3 | 1.405 (1.330–1.485) | <0.001 | |
| Nx | 1.284 (1.168–1.411) | <0.001 | |
| Primary Site | <0.001 | 0.005 | |
| Main bronchus | Reference | ||
| Lobe | 0.882 (0.814–0.956) | 0.002 | |
| Overlapping lesion | 1.040 (0.860–1.259) | 0.683 | |
| Lung, NOS | 0.902 (0.822–0.989) | 0.029 | |
| Laterality | 0.821 | ||
| Left | |||
| Right | |||
| Others | |||
| With M1a | <0.001 | <0.001 | |
| No | Reference | ||
| Yes | 1.146 (1.100–1.194) | <0.001 | |
| Bone metastasis | <0.001 | <0.001 | |
| No | Reference | ||
| Yes | 1.275 (1.221–1.331) | <0.001 | |
| Brain metastasis | <0.001 | <0.001 | |
| No | Reference | ||
| Yes | 1.185 (1.134–1.238) | <0.001 | |
| Liver metastasis | <0.001 | <0.001 | |
| No | Reference | ||
| Yes | 1.339 (1.283–1.397) | <0.001 | |
| Radiation | <0.001 | 0.143 | |
| No | |||
| Yes | |||
| Chemotherapy | <0.001 | <0.001 | |
| No/Unknown | Reference | ||
| Yes | 0.421 (0.405–0.437) | <0.001 | |
| Surgery | <0.001 | <0.001 | |
| No | Reference | ||
| Yes | 0.568 (0.501–0.642) | <0.001 | |
Abbreviation: OS, overall survival.