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. 2010 Jan 20;15(1):442–459. doi: 10.3390/molecules15010442

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© 2010 by the authors;

licensee Molecular Diversity Preservation International, Basel, Switzerland. This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).

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Scheme 5 — Synthesis of neurotransmitters in the brain. (A) Serotonin (34) is synthesized from L-tryptophan (15) via the intermediate 5-hydroxytryptophan (37). (B) Dopamine (35) is formed from L-tyrosine (39) via DOPA (38), and (C) GABA (36) is formed in a decarboxylation reaction from L-glutamate (40).