. 2018 Nov 22;10:6167–6179. doi: 10.2147/CMAR.S171035

Table S1.

Details of blood testing time, treatment methods, and NOS score of included studies

Study	Blood exam time	Treatment	Quality assessment with NOS
Study	Blood exam time	Treatment	Selection	Comparability	Outcome

Yang et al (2018)¹	Before surgery	Surgery ± adj CRT	*******	**	*******
Kunizaki et al (2018)²	Before treatment	Surgery/other	*******	*	**
Sato et al (2017)³	Before treatment	CRT	*******	*	**
Kijima et al (2017)⁴	Within 2 weeks before treatment	CRT	*******	**	**
Gao et al (2017)⁵	Before treatment	Surgery ± adj CRT	*******	**	**
Miao et al (2017)⁶	Before treatment	CRT	*******	**	**
Zhou et al (2017)⁷	Before CRT	CRT	*******	**	*******
He et al (2017)⁸	Within 1 week before surgery	Surgery ± adj CRT	********	**	*******
Liu et al (2017)⁹	Within 1 week before CRT	CRT	*******	**	**
Zhang et al (2016)¹⁰	Before CRT	CRT	*******	*	**
Zhang et al (2016)¹¹	Within 5 days before surgery	Surgery ± adj CRT	*******	*	**
Toyokawa et al (2016)¹²	Before treatment	± NAC + surgery ± adj CMT	*******	*	*******
Hirahara et al (2016)¹³	1 week before surgery	Surgery	*******	**	*******
Ikeguchi et al (2016)¹⁴	Before NAC/surgery	± NAC + surgery ± adj CT	*******	*	**
Geng et al (2016)¹⁵	Before surgery	Surgery	********	**	*******
Xiao et al (2016)¹⁶	Within 2 weeks before CRT	Surgery ± adj CRT	********	**	*******
Zhu et al (2017)¹⁷	Within 3 days prior to surgery	Surgery ± adj CRT	*******	**	*******
Huang and Feng (2015)¹⁸	Within 1 week before surgery	Surgery ± adj CRT	*******	*	*******
Han et al (2015)¹⁹	Within 1 week before surgery	Surgery ± adj CRT	*******	**	*******
Ji et al (2016)²⁰	Before NAC	NAC + S	*******	*	*******
Jung et al (2016)²¹	Within 1 week before surgery	Surgery ± adj CMT	*******	*	**
Kosumi et al (2016)²²	Before NAC/surgery	± NAC + surgery ± adj CMT	*******	*	**
Arigami et al (2015)²³	Within 2 weeks before surgery	Surgery	*******	*	*******
Duan et al (2015)²⁴	Within 1 week before surgery	Surgery	*******	**	*******
Xie et al (2016)²⁵	Within 10 days before surgery	Surgery ± adj CMT	*******	*	**
Feng et al (2014)²⁶	Within 1 week before surgery	Surgery	*******	**	*******

Abbreviations: NOS, Newcastle–Ottawa scale; CRT, chemoradiotherapy; CT, computed tomography; adj, adjuvant; S, surgery; NAC, neoadjuvant chemotherapy; CMT, chemoradiotherapy.