Table 3.
Alanine aminotransferase activity (U/L) in plasma 24 h after acetaminophen administration (150 mg/kg i.g). Tested substances were given intraperitoneally 1 h before acetaminophen. P value is a result of comparison with the control group (Steel’s test).
| Substance | Mean | SD | Median | P value |
|---|---|---|---|---|
| Control 0.9% NaCl | 9550.0 | 9213.2 | 7321.5 | |
| α-MSH 6 × 10-8 mol/kg* | 8983.7 | 4654.4 | 7901.0 | 0.962 |
| α-MSH 3 × 10-7 mol/kg* | 4292.0 | 1422.1 | 3945.0 | 0.999 |
| α-MSH 6 × 10-7 mol/kg* | 2671.3 | 2235.1 | 2167.5 | 0.390 |
| α-MSH 1.5 × 10-6 mol/kg* | 585.8 | 1424.1 | 89.0 | 0.012 |
| α-MSH 3 × 10-6 mol/kg | 16853.0 | 10676.0 | 18100.0 | 0.397 |
| β-MSH 5 × 10-8 mol/kg | 2766.5 | 2693.6 | 2119.0 | 0.270 |
| β-MSH 1 × 10-7 mol/kg | 55.3 | 17.7 | 56.5 | 0.003 |
| β-MSH 2 × 10-7 mol/kg | 811.4 | 440.6 | 808.5 | 0.003 |
| β-MSH 4 × 10-7 mol/kg | 2368.5 | 3033.9 | 1322.0 | 0.041 |
| γ-MSH 5 × 10-8 mol/kg | 107.8 | 52.0 | 82.0 | 0.003 |
| γ-MSH 1 × 10-7 mol/kg | 75.8 | 23.5 | 82.5 | 0.003 |
| γ-MSH 2 × 10-7 mol/kg | 85.1 | 37.5 | 80.5 | 0.003 |
| γ-MSH 4 × 10-7 mol/kg | 340.4 | 216.0 | 340.0 | 0.003 |
* Turčić et al. [23].