Table 5.
Number and percentage of animals with histopathology score ≥ 3, 24 h after acetaminophen administration (150 mg/kg i.g.). Tested substances were given intraperitoneally 1 h before acetaminophen. P value is a result of comparison with the control group (Fisher exact probability test).
| Substance | Histopathology score ≥ 3 | P value |
|---|---|---|
| Control 0.9% NaCl | 7/8 (87.5%) | |
| α-MSH 6 × 10-8 mol/kg | 6/6 (100%) | 0.999 |
| α-MSH 3 × 10-7 mol/kg | 6/6 (100%) | 0.560 |
| α-MSH 6 × 10-7 mol/kg | 2/7 (28.6%) | 0.032 |
| α-MSH 1.5 × 10-6 mol/kg | 2/8 (25.0%) | 0.018 |
| α-MSH 3 × 10-6 mol/kg | 8/8 (100%) | 0.999 |
| β-MSH 5 × 10-8 mol/kg | 4/8 (50.0%) | 0.047 |
| β-MSH 1 × 10-7 mol/kg | 0/8 (0.00%) | 0.002 |
| β-MSH 2 × 10-7 mol/kg | 0/8 (0.00%) | 0.004 |
| β-MSH 4 × 10-7 mol/kg | 3/8 (37.5%) | 0.041 |
| γ-MSH 5 × 10-8 mol/kg | 0/8 (0.00%) | 0.002 |
| γ-MSH 1 × 10-7 mol/kg | 0/8 (0.00%) | 0.002 |
| γ-MSH 2 × 10-7 mol/kg | 0/8 (0.00%) | 0.002 |
| γ-MSH 4 × 10-7 mol/kg | 0/8 (0.00%) | 0.003 |