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Comparison of mutational pattern comparing gastrointestinal stromal tumor (GIST) primary tumors (Mannheim Registry, 2004-2017, n = 822). Left side: Distribution in the overall group with mutational data available irrespective of tumor size (n = 516). Right side: Subgroup of locally advanced GIST in which neoadjuvant treatment could be considered, i.e. esophageal GIST > 5 cm, gastric GIST > 10 cm, and duodenal/rectal GIST > 6 cm.
