Table 2.
Anti-angiogenic activity of compounds 1-6, 9-17.
| Compound | Concentration (μg/mL) |
Intersegmental Vessels (ISV) | Inhibition Ratio (%) |
|---|---|---|---|
| 1 | 100 | 24.7 ± 1.2 | 8.0 |
| 2 | 100 | 26.7 ± 1.2 | 0.5 |
| 3 | 100 | 26.0 ± 0.0 | 3.0 |
| 4 | 100 | 24.7 ± 1.2 | 8.0 |
| 5 | 100 | 24.7 ± 1.2 | 8.0 |
| 6 | 100 | 20.0 ± 2.8 | 25.4 |
| 9 | 50 | 9.4 ± 8.4 ** | 64.9 |
| 10 | 100 | 26.7 ± 1.2 | 0.5 |
| 11 | 100 | 26.7 ± 1.2 | 0.5 |
| 12 | 100 | 26.3 ± 1.5 | 1.7 |
| 13 | 100 | 24.7 ± 0.6 | 8.0 |
| 14 | 100 | 26.3 ± 0.6 | 1.7 |
| 15 | 100 | 25.0 ± 0.0 | 6.7 |
| 16 | 100 | 24.7 ± 2.3 | 8.0 |
| 17 | 100 | 27.0 ± 1.0 | 0 |
| control a | 26.8 ± 1.8 | ||
| PTK787 | 10 | 0 ** | 100 |
a 0.1% DMSO in sterile salt water; ** means that the value was significantly different from the control and p < 0.01.