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. 2018 Aug 2;84(Suppl 1):18–29. doi: 10.1038/s41390-018-0079-8

Table 2.

Peak systolic (s′), early diastolic (e′), and late diastolic (a′) velocities and displacement of the AV-valve plane in premature and mature neonates. Pulsed-wave (pwTDI) and color-coded tissue Doppler (cTDI) indices (mean (standard deviation)). GA: Gestational age

Reference and TDI mode Index Location
Left lateral Septum Right lateral
Lee et al.38 cTDI
GA < 28 weeks
First 24 h
Systolic peak (s′) (cm/s) 1.8 (0.7) 2.8 (0.9)
Diastolic peak (cm/s) 2.3 (1.1) 4.1 (1.6)
Displacement (mm) 1.9 (0.9) 3.3 (1.2)
Joshi et al.12 cTDI
Premature (≤34 weeks) and mature (≥38 weeks)
Within first 72 h
Systolic peak (s′) (cm/s) 2.4 (0.9) 2.9 (0.9) 4.4 (1.1)
Early diastolic peak (e′) (cm/s) 4.9 (2.4) 4.7 (2.3) 6.2 (2.7)
Late diastolic peak (a′) (cm/s) 2.9 (1.0) 3.7 (1.1) 5.8 (1.3)
Displacement (mm) 3.9 (1.7) 4.7 (1.2) 7.5 (1.9)
Saleemi et al.53 pwTDI
GA 24–27 weeks
48 h of age
Systolic peak (s′) (cm/s) 3.5 (1.0)
Early diastolic peak (e′) (cm/s) 3.8 (0.9)
Late diastolic peak (a′) (cm/s) 4.3 (1.0)
GA 28–31 weeks
48 h of age
Systolic peak (s′) (cm/s) 3.8 (0.8)
Early diastolic peak (e′) (cm/s) 3.9 (1.0)
Late diastolic peak (a′) (cm/s) 4.2 (0.7)
GA 32–35 weeks
48 h of age
Systolic peak (s′) (cm/s) 4.7 (1.2)
Early diastolic peak (e′) (cm/s) 4.8 (1.2)
Late diastolic peak (a′) (cm/s) 5.2 (0.9)
Breatnach et al.55
GA < 29 weeks
First 24 h (see paper for further time points)
Systolic peak (s′) (cm/s) 2.8 (0.9) 2.4 (0.6) 3.6 (0.9)
Early diastolic peak (e′) (cm/s) 3.6 (1.4) 2.8 (0.8) 3.9 (1.3)
Late diastolic peak (a′) (cm/s) 4.0 (1.5) 3.9 (1.1) 3.9 (1.1)
Ciccone et al.54 pwTDI
GA 31–36 weeks
Days 3–4
Systolic peak (s′) (cm/s) 5.4 (0.8) 4.5 (1.4) 5.5 (0.9)
Early diastolic peak (e′) (cm/s) 7.6 (1.2) 2.7 (0.7) 6.2 (1.3)
Late diastolic peak (a′) (cm/s) 7.5 (1.3) 6.5 (0.7) 9.4 (1.1)
GA 37–41 weeks
Day 3–4
Systolic peak (s′) (cm/s) 5.6 (0.8) 5.1 (0.4) 6.1 (0.9)
Early diastolic peak (e′) (cm/s) 7.9 (1.2) 6.1 (0.8) 7.9 (1.1)
Late diastolic peak (a′) (cm/s) 7.5 (1.3) 6.7 (0.8) 9.5 (1.1)
Negrine et al.51 pwTDI
GA < 30 weeks
First 24 h
Systolic peak (s′) (cm/s) 3.7 (0.6) 5.0 (0.6)
Early diastolic peak (e′) (cm/s) 4.2 (0.8) 4.2 (1.1)
Late diastolic peak (a′) (cm/s) 5.4 (2.2) 7.3 (1.1)
GA 30–36 weeks
First 24 h
Systolic peak (s′) (cm/s) 4.3 (0.7) 5.9 (0.9)
Early diastolic peak (e′) (cm/s) 5.7 (1.4) 6.2 (1.0)
Late diastolic peak (a′) (cm/s) 6.0 (1.9) 7.7 (1.8)
Term
First 24 h
Systolic peak (s′) (cm/s) 5.3 (1.0) 6.9 (1.2)
Early diastolic peak (e′) (cm/s) 6.4 (1.2) 7.3 (1.1)
Late diastolic peak (a′) (cm/s) 7.1 (1.8) 8.1 (1.6)
Mori et al.32 pwTDI
Term
First 24 h
Systolic peak (s′) (cm/s) 5.3 (0.9) 3.7 (0.6) 6.2 (1.1)
Early diastolic peak (e′) (cm/s) 7.5 (1.5) 5.0 (1.0) 7.5 (1.4)
Late diastolic peak (a′) (cm/s) 6.2 (1.4) 4.9 (1.0) 9.2 (1.6)