Table 2.
Feature comparison of phage display and SELEX-derived binders.
| Binder | Peptide | Antibody | RNA | DNA | Spiegelmer |
|---|---|---|---|---|---|
| Biological stability | medium | strong | low | medium | strong |
| Chemical stability | strong | low-medium | medium | strong | as RNA or DNA |
| M ultiple regeneration | yes | no | yes | yes | yes |
| Synthesis | chemical/in vivo | cell culture | chemical/in vivo | chemical | chemical |
| Adverse immune reactions | no (size and structure dependent) | yes (needs humanisation) | no | no | no |
| Synthesis cost | low-medium | high | low-medium | low | medium-high |
| Selectivity/affinity | low-medium | high | high | medium-high | as RNA or DNA |