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. 2010 Apr 13;15(4):2686–2718. doi: 10.3390/molecules15042686

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© 2010 by the authors;

licensee Molecular Diversity Preservation International, Basel, Switzerland. This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).

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Scheme 10 — Synthesis of ¹²⁴I-labeled EGFR-inhibitors: a) Sn₂Bu₆, Pd(PPh₃)₄, THF; b) [¹²⁴I]NaI, NaOH, HCl, Chloramin T; c) BrCH₂CHCHCOCl; d) Me₂NH; e) ClCH₂COCl; f) MeOCH₂COCl.