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. 2010 Apr 16;15(4):2814–2824. doi: 10.3390/molecules15042814

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© 2010 by the authors;

licensee Molecular Diversity Preservation International, Basel, Switzerland. This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).

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Effects of GP-EX on the levels of dopamine, DOPAC, HVA and norepinephrine in the striatum of 6-OHDA-lesioned rats. GP-EX (10 and 30 mg/kg) was administered orally to 6-OHDA-lesioned rats from day 3 post-lesion for 28 days. The levels of dopamine, DOPAC, HVA and norepinephrine in the striatum were determined by HPLC method. Results are represented as means ± S.E.M of four experiments. Sham-lesioned groups (A), 6-OHDA-lesioned groups (B), GP-EX-administered groups [10 mg/kg (C) and 30 mg/kg (D)] in 6-OHDA-lesioned rats. * p < 0.05 compared with sham groups; # p < 0.05 compared with 6-OHDA-lesioned groups (ANOVA followed by Tukey’s test).