Table 1.
Genes determining sensitivity or resistance towards ART in the panel of 39 cell lines as identified by microarray mRNA expression profiling and COMPARE analysis.
| RESISTANCE GENES | ||||
|---|---|---|---|---|
| Gene | UNIQID | Pearson | Name | Function |
| SLC30A1 | R31110 | 0.552 | Human hbc647 mRNA sequence | Involved in zinc transport out of the cell. |
| GFAP | AA069414 | 0.552 | Glial fibrillary acidic protein | Class-III intermediate filament |
| BDKRB2 | AA194043 | 0.513 | Bradykinin receptor B2 | Receptor for bradykinin |
| AKR1C3 | AA916325 | 0.511 | Aldo-keto reductase family 1, member C3 | Member of the aldo/keto reductase superfamily |
| SNAP23 | N32278 | 0.472 | Synaptosomal-associated protein, 23kD | Regulator of membrane fusion machinery and transport vesicle docking |
| KYNU | H87471 | 0.471 | Kynureninase (L-kynurenine hydrolase) | Cleaves L-kynurenine and L-3-hydroxykynurenine |
| AKR1C1 | R93124 | 0.453 | Aldo-keto reductase family 1, member C1 | Member of the aldo/keto reductase superfamily |
| ITPK1 | AA463931 | 0.452 | Inositol 1,3,4-triphosphate 5/6 kinase | Phosphorylates various inositol polyphosphates |
| not specified | H44051 | 0.443 | not specified | Member of the keratin family |
| ALDH3A1 | AA069024 | 0.435 | Aldehyde dehydrogenase 3 family, member A1 | ALDH oxidizes various aldehydes to the corresponding acids. |
| GYS2 | N52282 | 0.432 | Glycogen synthase 2 (liver) | Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan |
| KRT4 | AA629189 | 0.425 | Keratin 4 | Member of the keratin gene family |
| CD24 | H59916 | 0.423 | CD24 antigen (small cell lung carcinoma) | Signal transducer; modulates B-cell activation |
| SMAD3 | W72201 | 0.423 | Similar to mothers against decapentaplegic homolog 3 | Transcriptional modulator; plays a role in carcinogenesis |
| CREB3L3 | AI952482 | 0.415 | Sirtuin 6 | Glycosyl transferase activity |
| SLC12A7 | AA427732 | 0.402 | Solute carrier 12 (potassium/chloride transporters) | Important for the survival of cochlear outer and inner hair cells |
| SLC22A5 | AI933276 | 0.398 | Solute carrier 22 (organic cation transporter) | Involved in the active cellular uptake of carnitine. |
| FETUB | AA705308 | 0.396 | Fetuin B | Member of the fetuin family |
| TRAM1 | H15707 | 0.366 | Translocating chain-associating membrane protein | Translocation of secretory proteins across the ER membrane |
| WNT7A | AI885451 | 0.365 | Wingless-type MMTV integration site family | Involved in oncogenesis |
| DCDC2 | AA127741 | 0.360 | Doublecortin domain containing 2 | Enhances microtubule polymerization |
| ERRFI1 | AA400258 | 0.359 | Gene 33/Mig-6 | Involved in cell signaling and cell stress |
| ABCC3 | AA429895 | 0.357 | ATP-binding cassette, sub-family C (CFTR/MRP) | Member of the superfamily of ABC-Transporters |
| IKBKG | R56102 | 0.357 | Homo sapiens cDNA FLJ20586 fis, clone KAT09466 | Regulatory subunit of the inhibitor of kappaB kinase (IKK) |
| S100A10 | AA444051 | 0.354 | S100 calcium-binding protein A10 | Regulation of cellular processes such as cell cycle progression and differentiation |
| GSR | AA777289 | 0.352 | Glutathione reductase | Maintains high levels of reduced glutathione in the cytosol |
| ST8SIA1 | AA169183 | 0.349 | Sialyltransferase 8 A | Cell adhesion and growth of cultured malignant cells |
| CUL5 | AA086475 | 0.337 | Cullin 5 | May form a cell surface vasopressin receptor |
| SCAP | R54823 | 0.335 | Srebp cleavage-activating protein | Regulates sterol biosynthesis |
| AKR1B1 | AA701963 | 0.330 | Aldo-keto reductase family 1, member B1 | Member of the aldo/keto reductase superfamily |
| ATP1B1 | AA598814 | 0.329 | ATPase, Na+/K+ transporting, beta 1 polypeptide | Catalyzes ATP hydrolysis and ion exchange across plasma membranes |
| VCAN | AA101875 | 0.326 | Chondroitin sulfate proteoglycan 2 (versican) | May play a role in intercellular signaling, cell mobility and differentiation |
| TRIM21 | N45131 | 0.309 | Sjögren syndrome antigen A1, tripartite motif-containing 21 | Ribonucleoprotein particle which binds DNA, RNA, protein and zinc |
| GLRX | AA291163 | 0.307 | Glutaredoxin (thioltransferase) | Reduces low molecular weight disulfides and proteins |
| SLC23A1 | AI934925 | 0.306 | Solute carrier family 23 (nucleobase transporters) | This gene encodes one of the Vitamin C transporters |
| SENSITIVITY GENES | ||||
| Gene | UNIQID | Pearson | Name | Function |
| RPL29 | AW073449 | -0.300 | Ribosomal protein L29 | Cytoplasmic ribosomal protein of the 60S subunit |
| PSMB5 | AA864479 | -0.304 | Proteasome (prosome, macropain) subunit, β type | May catalyze basal processing of intracellular antigens |
| DDR2 | AA243749 | -0.308 | Discoidin domain receptor family, member 2 | Tyrosine kinase receptor mediating fibroblast migration and proliferation |
| ASNS | AA894927 | -0.309 | Asparagine synthetase | Synthesis of asparagine |
| LDHB | AI969670 | -0.310 | Lactate dehydrogenase B | Oxidoreductase activity |
| RAD23A | H99170 | -0.310 | RAD23 homolog A (S. cerevisiae) | Molecular calcium binding chaperone |
| CSE1L | N69204 | -0.312 | Chromosome segregation 1 (yeast homolog)-like | May play a role in apoptosis and cell proliferation |
| INSIG1 | H59620 | -0.314 | Insulin induced gene 1 | May play a role in growth and differentiation of tissues involved in metabolic control |
| PABPCP5 | AA486531 | -0.315 | Poly(A)-binding protein, cytoplasmic 1 | May be involved in translationally coupled mRNA turnover |
| ATOX1 | AA418694 | -0.315 | Antioxidant protein 1 (yeast) homolog 1 | May play a role in carcinogenesis |
| PRKCSH | AA496810 | -0.316 | Protein kinase C substrate 80K-H | Acidic phospho-protein known to be a substrate for protein kinase C |
| AA878561 | -0.319 | Ubiquitin A-52 residue ribosomal protein product | Regulation of gene expression | |
| ISG15 | AA406020 | -0.319 | Interferon-stimulated protein, 15 kDa | May regulate proteins involved in the release of prostaglandin F2-alpha (PGF) |
| EEF2 | R43766 | -0.322 | Eukaryotic translation elongation factor 2 | Essential factor for protein synthesis |
| R37276 | -0.322 | Eukaryotic translation initiation factor 4 gamma, 1 | Recognition of the mRNA cap | |
| PCDH17 | AA969048 | -0.326 | Protocadherin 17 | May play a role for cell-cell connections in the brain |
| PHB2 | AA464567 | -0.328 | B-cell associated protein | Functions as an estrogen receptor |
| TIMM17A | AA708446 | -0.335 | Translocase of inner mitochondrial membrane 17 | Translocation of transit proteins across mitochondrial membrane |
| RRAS | AI368184 | -0.337 | Related RAS viral (r-ras) oncogene homolog | Regulates the organization of the actin cytoskeleton |
| SYNCRIP | AA186327 | -0.338 | Synaptotagmin binding, cytoplasmic RNA binding protein | Involved in mRNA processing |
| AA448261 | -0.345 | High-mobility group protein isoforms I and Y | Gene transcription, integration of retroviruses into chromosomes and metastasis | |
| RPL18A | W81118 | -0.356 | EST, similar to human 60S Ribosomal Protein L18A | unknown |
| RPS10 | AI611010 | -0.357 | Ribosomal protein S10 | Catalyzes protein synthesis. Variable expression of this gene in colorectal cancers |
| UBB | AW078798 | -0.358 | Ubiquitin B | Regulation of gene expression |
| RPSA | AA629897 | -0.367 | Laminin receptor 1 (67kD, ribosomal protein SA) | Up-regulation in cancer cells associated with invasion and metastasis |
| PRMT1 | N55480 | -0.381 | HMT1 (hnRNP methyltransferase)-like 2 | Arginine methyltransferase |
| LMAN1 | AA446103 | -0.386 | Lectin, mannose-binding, 1 | Type I integral membrane protein |
| YBX1 | AA599175 | -0.418 | Nuclease sensitive element binding protein 1 | May play a role in DNA repair |