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Impact of nanoparticles on the percentages of lung cancer initiating cells. The experiment involved evaluation of the tumorsphere formation assay. Representative images of tumorspheres in (A) H446 and (B) A549 cells are shown. Quantitative analysis of the tumorspheres in (C) H446 and (D) A549 cells. Data are presented as the mean ± standard deviation (n=6). *P<0.05; **P<0.01. Scale bars, 100 µm. RA, retinoic acid; LPNPs, lipid poly(lactic-co-glycolic acid).
