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. 2010 Apr 1;15(4):2374–2387. doi: 10.3390/molecules15042374

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© 2010 by the authors;

licensee Molecular Diversity Preservation International, Basel, Switzerland. This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).

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A) Keratinizing squamous carcinoma. GLUT1, prostromal staining pattern. Note positivity at periphery of tumour nest, in non-keratinizing basaloid cells, and loss of GLUT1 expression accompanying keratinization at the centre of tumour nest, 200×; B) 400×; C) Non - keratinizing poorly differentiated carcinoma, 100×. In the absence of squamous differentiation/keratinization: GLUT1 displays an antistromal pattern, suggestive of hipoxia-driven GLUT1 induction. D) and E) Basal staning pattern with the superficial layers showing little or no GLUT1 staining in the normal epithelium; F) GLUT1 immunostain (arrow). Squamous intraepithelial neoplasia, non- staining of basal layer.