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. 2018 Oct 23;10(11):3076–3088. doi: 10.1093/gbe/evy234

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© The Author(s) 2018. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Fig. 3. — —Enzymes with high superessentiality evolve more slowly. (A) Scatter-plot showing the negative association between enzyme superessentiality in glucose (SI_glu) and evolutionary rate measured as d_N/d_S (Spearman’s ρ = −0.313, P = 6.4 × 10⁻¹⁴, n = 548). (B) Scatter-plot showing the association between enzyme superessentiality in 54 different carbon sources (SI₅₄) and d_N/d_S (Spearman’s ρ = −0.274, P = 6.7 × 10⁻¹¹, n = 548). In both panels, a dashed line shows the best linear fit to the data and is provided as a visual guide. Note the logarithmic scale of the y axes.