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. 2018 Oct 10;61(22):9952–9965. doi: 10.1021/acs.jmedchem.8b00883

Table 4. Different Mutations in DprE1 Conferring Different Levels of Resistance to P01.

DprE1 mutation MIC (μM) fold change
wild type 3.13 —
Y314H >50 >16
Y314C 25 8
N364Sa 2.34 0.75
P116Sa 18.8 6
a

Mutants raised against an undisclosed DprE1 inhibitor.