Table 3.
Results of Fenton reaction inhibition assay. Rutin at the molar excess of 50:1 or 10:1 to DNA base pare was compared with the tested compounds at the same molar excess. AUC – area under curve; CCC – covalent closed circle (superhelical form of plasmid); L – linear form of plasmid; OC – open circle (circular form of plasmid).
| Compound | AUC | Ratio CCC/ (OC+L) | Compound ratio/Rutin ratio | ||
|---|---|---|---|---|---|
| CCC | OC | L | |||
| 1 (50:1) | 569 | 1618 | 98 | 0.332 | 0.892 |
| 1 (10:1) | 453 | 3272 | 458 | 0.121 | 0.135 |
| 3 (50:1) | 708 | 3271 | 231 | 0.202 | 0.543 |
| 3 (10:1) | 229 | 3170 | 294 | 0.066 | 0.073 |
| 7 (50:1) | 514 | 2854 | 193 | 0.169 | 0.454 |
| 7 (10:1) | 564 | 2173 | 73 | 0.251 | 0.279 |
| Rutin (50:1) | 1288 | 3207 | 254 | 0.372 | 1 |
| Rutin (10:1) | 1942 | 1955 | 207 | 0.898 | 1 |
| Natural plasmid | 2790 | 386 | 193 | 4.819 | - |
| 2 (50:1) | 439 | 634 | - | 0.692 | 0.553 |
| 2 (10:1) | 152 | 1502 | - | 0.101 | 0.199 |
| 6 (50:1) | 1289 | 402 | - | 3.206 | 2.565 |
| 6 (10:1) | 656 | 1406 | - | 0.467 | 0.921 |
| 10 (50:1) | 194 | 1556 | 96 | 0.117 | 0.094 |
| 10 (10:1) | 189 | 1915 | 122 | 0.093 | 0.183 |
| Rutin (50:1) | 1055 | 843 | - | 1.251 | 1 |
| Rutin (10:1) | 806 | 1591 | - | 0.507 | 1 |
| Natural plasmid | 1507 | - | - | - | - |
| 5 (50:1) | 505 | 1379 | - | 0.366 | 0.491 |
| 5 (10:1) | - | 1373 | - | - | - |
| Rutin (50:1) | 1155 | 1493 | 57 | 0.745 | 1 |
| Rutin (10:1) | 535 | 1788 | 47 | 0.292 | 1 |
| Natural plasmid | 2166 | 258 | - | 8.395 | - |