Table IV.
Associations of three polymorphisms with IS severity and short-term recovery.
| A, SNPs associated with IS severity | ||||
|---|---|---|---|---|
| Genotype | Mild (n=218) | Severe (n=90) | OR (95% CI) | P-value |
| rs11018628 | ||||
| TT | 150 (68.8) | 60 (66.7) | 1 | |
| TC | 61 (28.0) | 27 (30.0) | 1.22 (0.70–2.14) | 0.476 |
| CC | 7 (3.2) | 3 (3.3) | 1.13 (0.28–4.63) | 0.863 |
| Dominant | 1.21 (0.71–2.08) | 0.478 | ||
| Additive | 1.16 (0.73–1.83) | 0.523 | ||
| rs1801133 | ||||
| TT | 82 (37.6) | 28 (31.1) | 1 | |
| TC | 94 (43.1) | 38 (42.2) | 1.24 (0.69–2.22) | 0.480 |
| CC | 42 (19.3) | 24 (26.7) | 1.74 (0.88–3.41) | 0.109 |
| Dominant | 1.32 (0.78–2.27) | 0.300 | ||
| Additive | 1.31 (0.94–1.84) | 0.115 | ||
| rs12645561 | ||||
| CC | 115 (52.6) | 60 (46.7) | 1 | |
| CT | 81 (37.3) | 27 (42.4) | 1.43 (0.83–2.47) | 0.201 |
| TT | 22 (10.1) | 3 (10.9) | 1.13 (0.72–1.76) | 0.596 |
| Dominant | 1.39 (0.83–2.32) | 0.213 | ||
| Additive | 1.21 (0.83–1.77) | 0.316 | ||
| B, SNPs associated with IS short-term recovery | ||||
| Genotype | Improvement (n=173) | No change/deterioration (n=135) | OR (95% CI) | P-value |
| rs11018628 | ||||
| TT | 109 (63.0) | 101 (74.8) | 1 | |
| TC | 57 (33.0) | 31 (23.0) | 0.59 (0.35–0.98) | 0.043 |
| CC | 7 (4.0) | 3 (2.2) | 0.47 (0.12–1.89) | 0.290 |
| Dominant | 0.57 (0.35–0.95) | 0.029 | ||
| Additive | 0.62 (0.40–0.96) | 0.032 | ||
| rs1801133 | ||||
| TT | 66 (38.2) | 44 (32.6) | 1 | |
| TC | 73 (42.2) | 59 (43.7) | 1.24 (0.73–2.11) | 0.423 |
| CC | 34 (19.6) | 32 (23.7) | 2.43 (0.76–2.69) | 0.269 |
| Dominant | 1.28 (0.79–2.08) | 0.315 | ||
| Additive | 1.20 (0.88–1.64) | 0.253 | ||
| rs12645561 | ||||
| CC | 81 (46.8) | 75 (55.6) | 1 | |
| CT | 74 (42.8) | 46 (34.1) | 0.67 (0.41–1.10) | 0.111 |
| TT | 18 (10.4) | 14 (10.3) | 0.92 (0.63–1.35) | 0.674 |
| Dominant | 0.71 (0.45–1.12) | 0.137 | ||
| Additive | 0.83 (0.59–1.16) | 0.273 | ||
Logistic regression analyses adjusted for age, sex, smoking, drinking, diabetes, hypertension, and total cholesterol.