ZEB2 overexpression abolishes the inhibitory effects of miR-598 overexpression in NSCLC cells. H522 and H460 cells were co-transfected with miR-598 mimics and pcDNA3.1 or pcDNA3.1-ZEB2. (A) At 72 h post transfection, the ZEB2 protein expression was determined by western blot analysis. (B) Cell proliferation and (C) invasion in the indicated cells were assessed using a CCK-8 and cell invasion assays, respectively (magnification, ×200). *P<0.05 vs. the miR-NC group; #P<0.05 vs. the miR-598 mimics+pcDNA3.1-ZEB2 group. NSCLC, non-small cell lung cancer; ZEB2, zinc finger E-box-binding homeobox 2; miR, microRNAl; NC, negative control.