Table 1.

In vitro cytotoxicities and antiparasitic activities of compounds 1-12.

Biological activities	Cytotoxicity				Antimalarial IC50		Leishmanicidal IC50
	MCR-5 cells		KB cells		Plasmodium falciparum FcB1 Colombia		Leishmania major
	10 µg/mL	1 µg/mL	10 µg/mL	1 µg/mL	µg/mL	µM	µg/mL	µM
(+)-Preocoteine 1	20		23		0.5	1.3	>100
(+)-O-Methylcassythine 7	61	4	49		3.1	8.6	ND
(-)-Armepavine 9	0		0		3.6	11.4	ND
(-)-Northalidasine 2	0		32		3.4	5.2	27	41
(-)-Northalrugosidine 3	77	0	51	0	2.7	4.3	30	48
(-)-Thalfoetidine 4	62	0	40		2.1	3.3	17	27
(-)-Northalfoetidine 5	6		44		2.8	4.5	39	63
(-)-Thaligosidine 6	61	0	47		1.2	2.0	38	61
(+)-Thalicberine 8	29		43		2.5	4.2	55	90
Thaliglucinone 10	79	21	76	24	2.4	6.7	63	173
Berberine 11	ND		ND		0.4	0.9	13	35
Pseudoberberine 12	ND		ND		0.5	1.3	3.5	9
Chloroquine					0.06	0.1
Pentamidine							28	82