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. 2018 Sep 17;16(6):4562–4568. doi: 10.3892/etm.2018.6748

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Copyright: © Chen et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 1. — Among the natural products screened in Tg(fli1a: EGFP)^y1 zebrafish, mundoserone was identified as an anti-angiogenic compound. Representative (A-C) bright-field and (D-F) fluorescent images of zebrafish embryos at 24 h post-fertilization treated with 0.1% dimethyl sulfoxide (control), 10 µM mundoserone or 5 µM PTK787 (positive control) for 24 h (magnification, ×40). (G-I) Magnification of images (D-F) (magnification, ×112.5). Compared with those in the control group, embryos treated with mundoserone presented with a lower number of incomplete ISVs and only occasional sprouts (asterisks) of the DA were observed. (J) Chemical structure of mundoserone. DLAV, dorsal longitudinal anastomotic vessels; ISVs, intersegmental vessels; DA, dorsal aorta; PCV, posterior cardinal vein.