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. 2018 Sep 17;16(6):4562–4568. doi: 10.3892/etm.2018.6748

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Copyright: © Chen et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 2. — Mundoserone inhibits the trunk angiogenesis of zebrafish in a dose-dependent manner. Representative (A-E) bright field and (F-J) fluorescent images of zebrafish embryos at 24 h post-fertilization treated with 0.1% dimethyl sulfoxide (control), mundoserone (2.5, 5 or 10 µM) or 5 µM PTK787 (positive control) for 24 h (magnification, ×40). (K-O) Magnification of images F-J (magnification, ×112.5). Compared with the control, embryos exposed to mundoserone exhibited a lower number of incomplete ISVs and only occasional sprouts (asterisks) of the DA were observed. Quantification of (P) the number of complete ISVs and (Q) inhibition rate in mundoserone-treated embryos. Values are expressed as the mean ± standard error of the mean (n=10). ***P<0.001. ns, not significant; DLAV, dorsal longitudinal anastomotic vessels; ISVs, intersegmental vessels; DA, dorsal aorta; PCV, posterior cardinal vein.