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. 2018 Nov 2;43(1):413–425. doi: 10.3892/ijmm.2018.3971

Figure 5.

Figure 5

Post-stroke social isolation impairs memory-associated behaviors during stroke recovery following ischemic stroke. (A) Spontaneous alternation rate in the Y-maze task was measured at 14 dpi (n=12). (B) Number of total arm entries in the Y-maze task among for groups at 14 dpi (n=12). (C) Time spent exploring the familiar objects in all groups during the training session at 14 dpi (n=12). (D) Time spent exploring the familiar and novel objects in all groups during the test session at 14 dpi (n=12). (E) Step-through latency times without shocks in all groups at 14 dpi (n=12). (F) Step-through latency times at 24 h following shocks during the retention test at 14 dpi (n=12). Data are presented as the mean ± standard error of the mean and were analyzed by one-way analysis of variance followed by Fisher’s Protected Least Significant Difference test. #P<0.05 and ##P<0.01. MCAO, middle cerebral artery occlusion; rTGF-β, recombinant mouse transforming growth factor-β; SI, socially isolated; PH, pair-housed; dpi, days post-ischemia.