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. 2018 Oct 23;43(1):336–344. doi: 10.3892/ijmm.2018.3948

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Copyright: © Zhang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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(A) Treatment schedule for the rats. (B) Body weight during the treadmill exercise. All rats received a standard diet, and body weights were measured weekly. No significant difference was detected between the control and OA group during exercise. Differences between control and OAE, OA and OAE groups in weeks 4 and 5 were significant. ^*P<0.05 and **P<0.01 vs. control group; ⁺P<0.05 and ⁺⁺⁺P<0.001 vs. OAE group. Results are expressed as the mean and 95% confidence interval (one-way analysis of variance; n=10 rats/group). MIA, monosodium iodoacetate; OA, osteoarthritis; OAE, OA with treadmill exercise.