Table I.
Characteristics of the paired patients congenital with hypopituitarism and controls in the discovery set.
| Characteristics | Congenital hypopituitarism, n=12 | Controls, n=12 | P-value |
|---|---|---|---|
| Basic information | |||
| Age, years | 21.58±2.71 | 24.00±3.67 | 0.081 |
| Height, cm | 169.0±8.72 | 173.0±5.17 | 0.185 |
| Weight, kg | 65.13±16.94 | 67.75±3.93 | 0.606 |
| BMI, kg/m2 | 22.42±3.95 | 22.70±1.92 | 0.827 |
| Tanner stage | G1/G2/G3 (3/6/3) | - | - |
| Thyroid function | |||
| FT3, pmol/l | 3.70 (2.69-6.34) | 4.22 (3.51-5.06) | 0.434 |
| FT4, pmol/l | 9.67 (6.86-17.19) | 13.52 (11.67-17.08) | 0.018 |
| TSH, µIU/l | 0.69 (0.00-5.94) | 1.80 (0.56-2.76) | 0.369 |
| Corticotropic function | |||
| Cortisol, µg/dl | 0.465 (0.01-5.55) | 12.41 (7.10-21.00) | <0.001 |
| ACTH, pg/ml | 9.09 (5.27-10.96) | 42.00 (20.00-55.00) | <0.001 |
| Gonadotropic function | |||
| LH, mIU/l | 0.11 (0.01-1.26) | 4.05 (1.47-5.29) | <0.001 |
| FSH, µIU/ml | 0.18 (0.02-1.70) | 4.97 (1.80-7.98) | <0.001 |
| PRL, ng/ml | 16.81 (2.21-49.13) | 8.58 (4.27-11.62) | 0.065 |
| E2, pg/ml | 20.00 (20.00-28.60) | 26.46 (20.00-35.40) | 0.087 |
| PROG, ng/ml | 0.10 (0.10-0.20) | 0.12 (0.10-0.79) | 0.017 |
| TESTO, ng/ml | 0.10 (0.10-2.00) | 4.75 (2.25-7.01) | <0.001 |
The data for basic information are presented as the mean ± standard deviation. All other data are presented as the median (range). ACTH, adrenocorticotropic hormone; BMI, body mass index; FT3, free thyroxine 3; FT4, free thyroxine 4; TSH, thyroid stimulating hormone; PRL, prolactin; PROG, progesterone; TESTO, testosterone; LH, luteinising hormone; FSH, follicle-stimulating hormone.