Table II.

Differentially methylated positions in the peripheral blood DNA of 12 paired patients with congenital hypopituitarism and controls in the discovery set.

Gene/CpG region	Gene symbol	CpG site	P-value	FDR P-value	β-differencea	Chr	Region
TSS1500Ind	C11orf41	cg08939373	0.0002	0.0391	−0.1453	11	-
	GPR77	cg15361750	<0.0001	0.0170	−0.1517	19	-
	LIMK2	cg01606027	0.0001	0.0277	−0.1715	22	N_Shore
	NEIL3	cg14022913	0.0001	0.0255	−0.1429	4	N_Shore
	SLC27A3	cg00421624	<0.0001	0.0052	−0.1515	1	N_Shore
	PRR4	cg23256579	<0.0001	0.0011	−0.1650	12	-
	GLRX	cg10949007	0.0001	0.0281	−0.2245	5	-
	HNRPLL	cg18107006	<0.0001	0.0043	−0.1682	2	S_Shore
	PIWIL2	cg03594078	<0.0001	0.0132	−0.1414	8	N_Shore
TSS200Ind	HIF3A	cg22891070	0.0001	0.0227	−0.1683	19	S_Shore
GENEBODY	AGA	cg09976051	0.0001	0.0264	−0.1792	4	N_Shore
	C20orf3	cg20661985	0.0001	0.0267	−0.1460	20	N_Shelf
	CCKBR	cg18706028	0.0001	0.0305	0.1487	11	Island
	DOT1L	cg04173586	0.0001	0.0212	−0.1632	19	S_Shore
	ECT2	cg10028625	0.0003	0.0455	−0.1628	3	-
	FLJ13197	cg21199922	<0.0001	0.0039	−0.1433	4	-
	KCNK5	cg05255811	<0.0001	0.0113	−0.1495	6	-
	N4BP1	cg27319917	<0.0001	0.0041	−0.1410	16	-
	NKG7	cg10126923	<0.0001	0.0013	−0.1487	19	S_Shelf
	PLEK	cg13468685	<0.0001	0.0045	−0.1444	2	-
	PLEKHM1P	cg06064179	0.0001	0.0335	−0.1433	17	N_Shelf
	PRPSAP2	cg14817867	<0.0001	0.0096	−0.1473	17	-
	RASA3	cg10800346	0.0001	0.0221	−0.1600	13	-
	REV3L	cg09365147	<0.0001	0.0156	−0.1423	6	-
	TAF1B	cg25588844	<0.0001	0.0021	−0.1572	2	-
	THOC7	cg22134162	<0.0001	0.0067	−0.1404	3	-
	TRIM35	cg05755408	<0.0001	0.0045	−0.1580	8	-
	VIM	cg26063719	<0.0001	0.0033	−0.1440	10	S_Shore
	WIPI1	cg25161129	<0.0001	0.0123	−0.1550	17	N_Shore
	FGGY	cg10220544	0.0003	0.0482	−0.1429	1	-
	KDM1A	cg25199552	0.0001	0.0333	−0.1476	1	S_Shelf
	RPTOR	cg27511181	<0.0001	0.0035	−0.1568	17	-
	RPTOR	cg06418238	<0.0001	0.0050	−0.1449	17	-
	THADA	cg22033476	<0.0001	0.0198	−0.1500	2	-
	CTSC	cg08522340	<0.0001	0.0038	−0.1503	11	N_Shelf
	DPH5	cg04205769	0.0001	0.0333	−0.1481	1	N_Shelf
	PROM1	cg17791799	0.0003	0.0456	−0.1434	4	-
UTR5Ind	AGPAT4	cg02627227	<0.0001	0.0033	−0.1600	6	-
	CPNE3	cg12162100	0.0003	0.0493	−0.1583	8	S_Shelf
	SYNE1	cg02841912	<0.0001	0.0051	−0.1408	6	N_Shore
UTR3Ind	PITPNB	cg26564117	<0.0001	0.0117	−0.1436	22	-
Intergenic	-	cg15986587	<0.0001	0.0159	−0.1789	19	N_Shelf
	-	cg16349093	<0.0001	0.0158	−0.1776	5	-
	-	cg21852792	<0.0001	0.0171	−0.1654	2	N_Shelf
	-	cg04075726	<0.0001	0.0079	−0.1627	2	-
	-	cg26828017	<0.0001	0.0192	−0.1584	16	-
	-	cg01861537	0.0001	0.0342	−0.1544	11	-
	-	cg09599062	<0.0001	0.0050	−0.1521	3	-
	-	cg12475879	0.0002	0.0394	−0.1518	17	S_Shelf
	-	cg01023672	0.0001	0.0383	−0.1461	12	S_Shelf
	-	cg04697624	<0.0001	0.0189	−0.1409	12	N_Shelf

^aβ-difference for the congenital hypopituitarism patients minus control. FDR, false discovery rate; Chr, chromosome.